PLoS ONE features reports of primary research from all disciplines within science and medicine. By not excluding papers on the basis of subject area, PLoS ONE facilitates the discovery of the connections between papers whether within or between disciplines.
But this is perhaps the most important distinction:
Too often a journal’s decision to publish a paper is dominated by subjective criteria, which can be frustrating and delay the publication of your work. PLoS ONE will publish all papers that are judged to be rigorous and technically sound. Judgments about the importance of any particular paper are then made after publication.
Read that last sentence a few times. That’s kinda the genius of the entire internet, isn’t it? Publish first, filter second!
(Via David Weinberger.)