Sad, Sad Ovoid
You’ve seen those Zoloft commercials with the sketchy little ovoid characters, right? Clive Thompson has an example, and a very mature disclaimer that I agree wholeheartedly with.
That said — this Flash parody made me laugh so hard I snorted grape juice out my nose! Well, almost.

There was a great parody of this commercial using E as the drug. Of course, I can’t find it; every google search redirects to a stupid drug-by-mail ordering page. I’ll keep looking.
Brilliant! Very cute music, too. My favorite part is the little bubbles dancing between the brain cells.